University of Aberdeen

Kang/Berg Lab

Understanding human brain development using advanced 3D models

We study how neural stem cells build the developing human brain and how environmental signals alter this process. Our work combines human fetal tissue with organoids, cerebroids and assembloids to investigate cortical and hippocampal development.

Fluorescence microscopy image from Kang/Berg Lab research

What we study

Research

We investigate how the human brain develops in health and disease. Our work centres on neural stem cells, tissue organisation and the environmental signals that shape early developmental trajectories.

01

Neural stem cells

We study how neural stem cells are regulated during cortical and hippocampal development and how they generate organised neural tissue.

02

Human 3D models

We develop organoids, cerebroids and assembloids incorporating microglia, vasculature and other cell types, as well as models of the developing choroid plexus.

03

Developmental disruption

We examine how maternal inflammation, stress and other physiological signals alter brain development and may shape trajectories relevant to neurodevelopmental conditions.

04

Alzheimer's disease and neurodegeneration

We use human iPSC-derived brain organoids and multicellular assembloids to investigate mechanisms relevant to neurodegenerative disease, including Alzheimer's disease. These models allow us to examine interactions among neurons, glia and vascular cells during disease-associated stress and inflammation.

We combine human experimental models with pharmacological and cytokine treatments, high-resolution imaging, histology, single-cell transcriptomics and spatial RNA sequencing.

Our team

People

Members of the Kang/Berg Lab in the Institute of Medical Sciences, 2026

Principal investigators

Eunchai Kang

Eunchai Kang

Group Leader

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Eunchai is a developmental neuroscientist and co-leads the Kang/Berg Lab. Her research uses human stem cell-derived models to investigate cortical development, neurogenesis and how environmental influences alter the developing brain.

Daniel A. Berg

Daniel A. Berg

Group Leader

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Daniel is a developmental neuroscientist and co-leads the Kang/Berg Lab. His research focuses on neural stem cells, hippocampal development and adult neurogenesis, combining human tissue with advanced 3D experimental models.

Current team

Richard Gyuris

Richard Gyuris

Research Technician · Joined 2024

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Richard is a Research Technician at the Institute of Medical Sciences, University of Aberdeen. He completed a bachelor's degree in Cell and Molecular Biology at the University of Szeged, Hungary, and a master's degree in Molecular Medicine at the University of Aberdeen. His experience includes RNA, DNA and protein work, histology, microscopy, tissue culture and work with laboratory animals.

Richard aims to continue broadening his knowledge and technical skills. Outside work, he enjoys hiking, gardening, aquascaping and keeping exotic pets.

Olivia Soper

Olivia Soper, PhD

Postdoctoral Researcher · Joined 2021

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Olivia joined the Kang/Berg Lab in 2021 for her PhD, where she developed and characterised human iPSC-derived hippocampal organoids for studying neurogenesis. Before moving to Aberdeen, she completed a BSc in Pharmacology and Physiology and an MSc in Neuroscience at the University of Manchester.

After completing her PhD in 2025, Olivia continued in the lab as a postdoctoral researcher. She now investigates how pharmacological compounds influence neural stem cell behaviour and neurogenesis in hippocampal organoids.

Outside the lab, she maintains another thriving culture: her sourdough starter. She is also a regular at the gym and recently taught herself to crochet.

Muhammad Z. K. Assir

Muhammad Z. K. Assir, MD, PhD

Research Fellow · Stem Cell Biologist

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Assir is a stem cell biologist driven by a simple but ambitious goal: to build better, and perhaps bigger, brains in the lab. His research focuses on developing and refining human stem cell-based models to understand brain development and disease, with a particular interest in creating new systems and pushing experimental boundaries.

Originally trained in medicine, Assir graduated from Allama Iqbal Medical College in Pakistan, completed a residency in Internal Medicine and later served as an Assistant Professor of Medicine. His journey from clinic to lab led him to the Kang/Berg Lab, where he completed his PhD and continues to explore the interface between biology and engineering.

At heart, Assir is endlessly inquisitive and eager to try new ideas, particularly when they involve building something that has not been built before. Outside the lab, he is a poet at heart and a proud dad to four energetic boys.

David Wragg

David Wragg, PhD

Computational Biologist · Joined 2024

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David is a computational biologist who joined both the Morgan and Kang/Berg labs in October 2024. He has extensive experience in genomics across a range of species, having worked at the University of Nottingham, INRAE Toulouse and the Roslin Institute. He applies single-cell omics to brain organoids to study neurological disorders.

Much of David's spare time is spent entertaining his two rescue dogs and his children. He enjoys international rugby, K-dramas, B-movies, tabletop gaming, painting and playing guitar. He is also a co-founder of BeeBytes Analytics CIC, a honey bee genetics community interest company.

Sara Valkila

Sara Valkila

PhD Student · Joined 2024

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Sara first joined the Kang/Berg Lab in 2022 as an undergraduate student assistant while completing her BSc in Biomedical Sciences (Anatomy) at the University of Aberdeen. Rooted in her anatomical training, she developed a strong interest in the structural organisation of the brain and how it is shaped during development. As an Amgen Scholar in 2023, Sara completed a summer placement at Ludwig Maximilian University of Munich, where she investigated the link between mutations in a tubulin gene and neurodevelopmental disease.

Sara returned to the lab for her PhD in 2024. She now investigates cortical interneuron development and models maternal inflammation using 3D human brain cultures. Her work connects detailed anatomical understanding with dynamic models of early neurodevelopment.

Outside the lab, Sara enjoys exploring Munros and coastal paths, walking in botanical gardens, attending weekly Pilates sessions and watching period dramas. She also cares for a growing collection of houseplants.

Gaby Crawford

Gabriella Crawford

PhD Student · Joined 2023

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Gaby joined the Kang/Berg Lab in 2023 for her PhD, using iPSC-derived brain organoids to investigate neuroimmune interactions in neurodevelopmental and neurodegenerative conditions. She aims to develop brain organoid cultures incorporating microglia and vasculature to better represent the human brain.

Before moving to Aberdeen, Gaby rowed competitively for 12 years and represented the University of Alabama while completing her BSc in Biology. She later completed an MSc in Stem Cell Technology and Regenerative Medicine at the University of Nottingham, where she discovered her interest in stem cells and organoid culture. In 2022, she worked in industry as a Research Scientist at Histologix before returning to academia.

Outside the lab, Gaby enjoys walking along Aberdeen beach, lifting at the gym and cooking, particularly trying to recreate her mum's authentic Mexican food.

Former lab members

Mario Yanakiev, PhD · Former PhD Student

Delia Ramirez, PhD · Former Postdoctoral Researcher

Olivia Soper · PhD completed 2025 · Now a Postdoctoral Researcher at the University of Aberdeen

Do Hyeon Gim · PhD completed 2025 · Now a Postdoctoral Researcher at the University of Oxford

Muhammad Z. K. Assir · PhD completed 2025 · Now a Postdoctoral Researcher at the University of Aberdeen

Former undergraduate and master's students: Beth Cavanagh, Naomi Sidabutar, Madhura Sham Nalawade, Malgorzata Michalik, Charlotte Colombo, Alicja Grzelak, Juri Westendorf, Anthony Gyening-Yeboah, Mohammad Kahn, Florence Roberts and Georgia Hepburn. List not exhaustive.

Selected work

Publications

Recent publications

Earlier highlights

  1. F. Ye, E. Kang, C. Yu, X. Qian, F. Jacob, C. Yu, M. Mao, R. Y. C. Poon, J. Kim, et al.

    DISC1 regulates neurogenesis via modulating kinetochore attachment of Ndel1/Nde1 during mitosis

    Neuron, 2017 · View publication

  2. X. Qian, H. N. Nguyen, M. M. Song, C. Hadiono, S. C. Ogden, C. Hammack, et al.

    Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure

    Cell, 2016 · View publication

  3. D. A. Berg, Y. Su, D. Jimenez-Cyrus, A. Patel, N. Huang, D. Morizet, et al.

    A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

    Cell, 2019 · View publication

  4. J. Shin, D. A. Berg, Y. Zhu, J. Y. Shin, J. Song, M. A. Bonaguidi, G. Enikolopov, et al.

    Single-cell RNA-seq with Waterfall reveals molecular cascades underlying adult neurogenesis

    Cell Stem Cell, 2015 · View publication

  5. E. Kang, J. Song, Y. Lin, J. Park, J. H. Lee, Q. Hussani, Y. Gu, S. Ge, et al.

    Interplay between a mental disorder risk gene and developmental polarity switch of GABA action leads to excitation-inhibition imbalance

    Cell Reports, 2019 · View publication

  6. E. Kang, D. Jiang, K. Y. Ryu, S. Lim, M. Kwak, C. D. Grey, M. Xu, J. H. Choi, et al.

    Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway

    PLoS Biology, 2017 · View publication

Beyond the lab

Outreach & Communications

Work with us

Join the Kang/Berg Lab

We welcome enquiries from motivated students and researchers interested in human brain development.

We are happy to support applications for independent postdoctoral fellowships. Please contact Daniel or Eunchai early to discuss potential projects and suitable funding schemes.

Undergraduate students interested in summer research projects are also encouraged to get in touch. The British Society for Developmental Biology offers Gurdon Studentships for summer vacation work.

Around Aberdeen

Lab Life

Kang/Berg Lab members at a group event Members of the Kang/Berg Lab Kang/Berg Lab group gathering Kang/Berg Lab social event Kang/Berg Lab members together Members of the Kang/Berg Lab and friends at Aberdeen beach Gaby presenting a research poster Human fetal brain cerebroids shown at different scales and labelled for cortical markers Members of the Kang/Berg Lab in an earlier outdoor group photograph

Get in touch

Contact

Kang/Berg Lab
Institute of Medical Sciences
University of Aberdeen
Foresterhill, Aberdeen AB25 2ZD, Scotland